It's hoped all six besties - Rachel, Monica, Phoebe, Joey, Chandler and Ross - will reunite for a tribute to legendary comedy director James Burrows, who also helmed series such as Taxi,The Bob Newhart Show and Cheers.
The special will focus on Burrows' career.
The news was announced at the Television Critics Association press tour in Pasadena on Wednesday, with the programme scheduled to air on US network NBC on Sunday, February 21.
All six leads - Jennifer Aniston, Courtenay Cox, Lisa Kudrow, Matt LeBlanc, Matthew Perry and David Schwimmer - are expected to come to the table for the special.
NBC chief Robert Greenblatt is hopeful the reunion will go ahead, but warned busy schedules may not make it possible.
"I'm hoping all six will be in the same room at the same time," he said. "I'm not sure we can logistically pull it off."
Friends fans have been hoping for a reunion for 11 years but cast members have remained vague on whether it will ever happen.