He accused Ms Heard of "building a dossier" against him after the court heard she wrote an email describing him as a Dr Jekyll and Mr Hyde character.
Mr Depp, 57, is suing the publisher of the Sun newspaper over an article that referred to him as a "wife beater".
The Sun has defended the accuracy of its story.
It had referred to "overwhelming evidence" that Mr Depp attacked Ms Heard, 34, during their relationship - which he strenuously denies.
Mr Depp is suing News Group Newspapers (NGN) and its executive editor Dan Wootton over the article, published in 2018.
Ms Heard claims that Mr Depp first hit her in early 2013 - one of 14 separate allegations of domestic violence, all denied by Mr Depp, which are being relied on by NGN in their defence.