Coach Steve Hansen has made nine personnel changes and a positional switch to his experimental starting team that saw off Argentina 46-24 in Nelson.
A fourth bonus point win from four matches would guarantee a third straight Rugby Championship crown for the world champions with two rounds of matches still to play.
Few would bet against it given the Springboks are coming off successive losses on the road and haven't won in New Zealand for nine years.
It hasn't stopped Hansen naming close to his strongest available team.
Barrett returns at five-eighth in place of Richie Mo'unga, in a first appearance since his four-try, 30-point haul against Australia at Eden Park.
One more Barrett try would give him 24 in the No.10 jersey, matching the world record set by his All Blacks predecessor Dan Carter.
Tryscoring specialist Ioane returns to the left wing, having recovered from a hamstring problem.
Six backline positions have new faces with Ben Smith the only player retained, although he moves to the right wing, with Jordie Barrett restored at fullback.
The halves and centres are both overhauled. Aaron Smith is halfback and Anton Lienert-Brown the outside centre while inside centre Ryan Crotty returns from a month on the sideline following a concussion early in the opening Bledisloe Cup Test in Sydney.
There is a place on the bench for Sonny Bill Williams, whose recuperation from a shoulder injury stretches back nearly three months.
Up front is more settled.
First-choice flankers Sam Cane and Liam Squire are recalled while Luke Whitelock replaces fellow lock veteran Brodie Retallick, who is injured.
The other lock is Scott Barrett, who will start alongside brothers Jordie and Beauden.
Whitelock's return means three centurions are in a battle-hardened pack, alongside Owen Franks and captain Kieran Read.
Forwards Patrick Tuipulotu and Liam Coltman have won rare selections, both on the bench.
ALL BLACKS: Jordie Barrett, Ben Smith, Anton Lienert-Brown, Ryan Crotty, Rieko Ioane, Beauden Barrett, Aaron Smith, Kieran Read (capt), Sam Cane, Liam Squire, Scott Barrett, Sam Whitelock, Owen Franks, Codie Taylor, Karl Tu'inukuafe. Res: Liam Coltman, Tim Perry, Ofa Tuungafasi, Patrick Tuipulotu, Ardie Savea, TJ Perenara, Sonny Bill Williams, Damian McKenzie.