Coachella was set to take place next month in the California desert with Rage Against the Machine and Frank Ocean among the headliners.
The event's organiser Goldenvoice has now postponed it until October, at the request of local health authorities.
Latest figures show the US has more than 950 confirmed cases of the disease and 28 deaths.
The Coachella Valley Music and Arts Festival is one of the world's most high-profile music events with many celebrity attendees.
