Kuechly left Thursday's game against the Philadelphia Eagles late in the second quarter to be evaluated for a concussion.
He was officially ruled out midway through the third quarter and the Panthers said he was in the concussion protocol.
Kuechly was injured on a short LeGarrette Blount run from the one-yard line. Kuechly rushed from the right side of the Eagles line as Blount was dropped for a one-yard loss on a run to the left. Kuechly sat on the turf at Bank of America Stadium before slowing getting up and being walked to the sideline by trainers.