An unspecified number of people will have the vaccine, as part of a trial by Hyderabad-based firm Bharat Biotech.
Tests in animals suggest the vaccine is safe and triggers an effective immune response.
The trials are among many across the world - there are around 120 vaccine programmes under way. Half a dozen Indian firms are developing vaccines.
This is the first India-made vaccine and developed from a strain of the virus that was isolated locally and weakened under laboratory conditions.