Reports had suggested Thomas could feature against the Boston Celtics on Wednesday, but he will instead come off the bench under a strict minutes restriction in Portland.
Thomas - who was traded to the Cavs from the Celtics in August - has missed the first 36 games of the season rehabbing a hip injury suffered in the post-season.
Coach Tyronn Lue is relishing having his new star available, and believes it will significantly strengthen the Cavs.
