The Celebration tour will now kick off in London on 14 October, three months after it was originally due to begin in Vancouver, Canada.
Most of the US dates have been pushed back to 2024, with some cancellations.
The tour was originally planned to celebrate the 40th anniversary of Madonna's breakout single, Holiday.
Dubbed the Celebration Tour, it marks her return to arenas and stadiums after the experimental, theatre-based Madame X shows in 2019 and 2020.