Etzebeth, a major enforcer in the Springbok pack, had been struggling with a shoulder problem picked up in the 18-3 victory over Scotland, but will line up alongside Franco Mostert in the second row.
It is the same starting XV that defeated the Scots, bar Bongi Mbonambi at hooker as he replaces Malcolm Marx, who has since been ruled out of the tournament with a knee injury.
Deon Fourie and Marco van Staden are the replacement hooker options, while the Munster lock pairing of RG Snyman and Jean Kleyn are also on the bench.