James Davies, younger brother of Wales and British and Irish Lions centre Jonathan, is one of the fresh faces brought in by Gatland for Sunday's match in Cardiff following a 37-27 defeat against Ireland 10 days ago.
Wing George North, centre Owen Watkin, flyhalf Gareth Anscombe and hooker Elliot Dee have all been handed starts.
The five starting XV survivors from Dublin are Liam Williams, who moves from wing to full-back instead of Leigh Halfpenny, wing Steffan Evans, centre Hadleigh Parkes, scrum-half Gareth Davies and lock Cory Hill.
