The grim milestone came on the same day as global coronavirus cases exceeded 50m.
The US has reported about a million cases in the past 10 days, the highest rate of infections since the nation reported its first novel coronavirus case in Washington state 293 days ago.
The country reported a record 131,420 Covid-19 cases on Saturday and has reported over 100,000 infections four times in the past seven days, according to a Reuters tally.
The US latest reported seven-day average of 105,600 daily cases, ramped up by at least 29 percent, is more than the combined average for India and France, two of the worst-affected countries in Asia and Europe.
More than 237,000 Americans have died of Covid-19 since the illness caused by the coronavirus first emerged in China late last year.
The daily average of reported new deaths in the US account for one in every 11 deaths reported worldwide each day, according to a Reuters analysis.
The number of reported deaths nationwide climbed by more than 1000 for a fifth consecutive day on Saturday, a trend last seen in mid-August, according to a Reuters tally.
Health experts say deaths tend to increase four to six weeks after a surge in infections.
US President-elect Joe Biden, who spent much of his election campaign criticising President Donald Trump's handling of the pandemic, pledged on Saturday to make tackling the pandemic a top priority.
Biden will announce a 12-member task force on Monday (US local time) to deal with the pandemic that will be led by former surgeon general Vivek Murthy and former Food and Drug Administration commissioner David Kessler. The coronavirus task force will be charged with developing a blueprint for containing the disease once Biden takes office in January.