The star also had the most-played song of the year with Bad Habits.
It's the fourth time in five years that Sheeran has been named the UK's most-played artist, calculated by plays on radio, TV, pubs, clubs and shops.
The singer last topped the most-played song chart in 2017 with Shape Of You, over which he recently won a High Court copyright case.
Sheeran's continued success is "a testament to the quality of his output [and] the strength of UK music at a time when the global music landscape is more competitive than ever," said PPL chief executive Peter Leatham.
But Bedford-born singer Tom Grennan could coming for Sheeran's crown.
The singer, who was recently hospitalised after being attacked in New York, had the second and third most-played songs of 2021.
His Calvin Harris collaboration, By Your Side, took the runner-up spot, with his solo single Little Bit of Love in third place.