Star midfielder Levani Botia, who captained Fiji against the All Blacks in July, will undergo a knee operation this month and has been replaced by Apisai Naqalevu.
Hooker Peni Narisia has been replaced by Zuriel Togiatama after suffering a calf injury, while veteran lock Api Ratuniyarawa has been called in to replace flanker Peceli Yato, who injured his knee playing for Clermont at the weekend.
Biarritz back-rower Johnny Dyer has also pulled out of the tour for personal reasons and the coaching staff is still weighing up whether to call in another player.
Meanwhile 20 year old Stade Francais hooker Henry Spring has been brought into the squad this week as part of a development opportunity.
The Flying Fijians will also play tests against Wales and Georgia this month.