Olympic Sevens gold medallist Josua Tuisova, who plies his trade at French giants Toulon, has been selected on the right wing, while Mosese Ducivaki, Sikeli Nabou and John Stewart are all included on the bench for the match at ANZ Stadium.
There are five furtherchanges to the starting fifteen with Sunia Koto, Tevita Cavubati, Peceli Yato, Patrick Osborne and Albert Vulivuli also getting an opportunity.
Osborne has also been named on the left wing after playing for the Highlanders against the British and Irish Lions last week and missing Fiji's earlier tests against the Wallabies and Azzurri.
Flying Fijians Head Coach, John McKee said the team needs to step up and take on the challenge against the Scots, who upset Australia in Sydney last weekend and could rise to fourth in the world rankings with a big victory.
"This Vodafone Flying Fijians selection must step up and take on the challenge we have against Scotland on Saturday," he said.
"It is no longer good enough to just challenge these top international teams we must start winning big games."
John McKee said the fifth-ranked visitors will be a step up from their 22-19 victory against Italy last weekend, which was won thanks to a drop goal in injury time by first five Ben Volavola.
"Scotland have come to Fiji with a lot of confidence from their win over Australia, they will be a more difficult opponent than Italy so we must be right on top of all aspects of our game," he said.
"They also have an excellent defensive team, we will have to be very patient in attack to create and finish off scoring opportunities.
"They bring a lot of variation in attack with an expansive game. Work rate and connection will be very important in our defensive effort on Saturday."
John McKee said he planned to name the 28-man squad for Rugby World Cup qualifying matches against Tonga and Samoa on Saturday night after the match and urged the players to make the most of their final opportunity to impress.
Peni Ravai, Sunia Koto, Kalivati Tawake, Tevita Cavubati, Leone Nakarawa, Dominiko Waqaniburotu, Peceli Yato, Akapusi Qera (c), Serupepeli Vularika, Ben Volavola, Patrick Osborne, Jale Vatubua, Albert Vulivuli, Josua Tuisova, Kini Murimurivalu
Reserves: Tuapati Talemaitoga, Joeli Veitayaki, Mosese Ducivaki, Sikeli Nabou, Naulia Dawai, Henry Seniloli, John Stewart, Benito Masilevu
Photo: PHOTOSPORT Fiji's Josua Tuisova is tackled during the men's rugby sevens final at the 2016 Rio Olympics.