The Steve Jackson coached side lost to USA 13-10 last week.
Filo Paulo remains in the second‑row while TJ Ioane moves from openside to number eight.
In the backs, outside centre Kieron Fonotia and full‑back Ahsee Tuala survive the cut.
Logovi'i Munipola, Motu Matu'u and Paul Alo Emile form an all‑new front‑row partnership and Kane Leaupepe joins Paulo in the second row.
Jack Lam captains Samoa for the fourth time at openside and Chris Vui packs down on the other flank.
Dwayne Polataivao and Ulu-pano Seuteni are the half‑backs, Reynold Lee‑Lo makes up the midfield with Fonotia and Belgium Tuatagaloa and Alapati Leiua line up on the wings.
This is the 52nd time that Samoa will be playing against Fiji.
Fiji lead the head‑to‑head 28‑20 with three draws.