By winning 4-0 at Swansea on Wednesday (Thursday NZ time), City racked up their 15th straight victory - a feat never achieved in the 129-year history of England's top division.
City are unbeaten after 17 games and have now scored 52 goals, the latest coming at Liberty Stadium through David Silva (2), Kevin De Bruyne and Sergio Aguero against last-placed Swansea.
West Ham United and All Whites stalwart Winston Reid kept Arsenal scoreless at the London Stadium to secure a 0-0 draw, but the Hammers still sit second-bottom of the table.
Second-placed Manchester United returning to winnings ways, beating Bournemouth 1-0 through Romelu Lukaku's goal at Old Trafford to keep the gap at the top to 11 points, but chasing down their cross-town rival looks to be a forlorn hope at this rate.
With Liverpool held 0-0 at home by West Bromwich Albion for a second straight draw at Anfield, Tottenham climbed back into fourth place - the final Champions League qualifying spot - thanks to a 2-0 win over Brighton at Wembley after goals from Serge Aurier and Son Heung-min.
Leicester City manager Claude Puel enjoyed his return to Southampton, where he was sacked in the off-season, as Riyad Mahrez, Shinji Okazaki (2) and Andy King scored in a thumping 4-1 victory. Maya Yoshida scored Southampton's consolation strike.
And Wayne Rooney scored Everton's winner to grab a 1-0 victory at Newcastle United.
Photo: GETTY IMAGES. Caption: Sergio Aguero celebrates scoring for Manchester City in rout of Swansea.