Japan's Osaka stunned the tennis world when she quit the claycourt major in Paris in May following her first-round match after being fined and threatened with disqualification when she refused to attend mandatory post-match press conferences.
The world number two, who said she had social anxiety, also skipped Wimbledon but is scheduled to play at the Tokyo Olympics and then in Montreal next month.
Osaka will be part of a women's field at the U.S. Open that will also include world number one Ash Barty, who lifted her second major title at Wimbledon earlier this month.
A total of 15 major winners, including Simona Halep and Garbine Muguruza, are scheduled to feature in the women's field at Flushing Meadows.
In the men's section, former champions Novak Djokovic, Roger Federer and Rafael Nadal -- currently tied for the men's record of 20 Grand Slam singles titles -- will resume their quest for more silverware in New York.