Banderas, star of The Mask of Zorro, Spy Kids, the Shrek series and dozens of other films, is in quarantine.
"I want to make the news public that today, August 10th, I am forced to celebrate my 60th birthday in quarantine, having tested positive for the COVID-19 illness caused by the coronavirus," Banderas said on Twitter.
"I'd like to add that I'm feeling relatively well, just a bit more tired than usual, and confident that I will recover as soon as possible," Banderas said, adding that he had reached 60 "full of desire and aspirations".