A veteran of 81 tests for the All Blacks, Kaino will play his final match at Eden Park when the Auckland-based Super Rugby side host the Reds on Friday night.
The 35-year-old flanker, player of the tournament during the All Blacks' run to the 2011 World Cup crown, will also notch his 137th Blues appearance.
Assuming he gets on the field in one of the team's final two games of the season, both away from home, Kaino will surpass Tony Woodcock as their second-most capped player behind only Keven Mealamu (164).