The 54-year-old was the only child of Elvis Presley and Priscilla Presley.
Priscilla confirmed the "devastating" news after earlier asking for prayers.
"It is with a heavy heart that I must share the devastating news that my beautiful daughter Lisa Marie has left us," Priscilla said in a statement.
"She was the most passionate, strong and loving woman I have ever known."
The announcement came hours after Lisa Marie was rushed to the hospital on Thursday (local time).
