The meeting is scheduled for Thursday, and Musk will take questions directly from Twitter employees, the source added.
The news, first reported by Business Insider, comes after Twitter said last week that it anticipated a shareholder vote on the sale by early August.
A Twitter spokesperson confirmed that Musk would attend the company all-hands meeting this week.
Ever since Musk's takeover bid, many Twitter employees have expressed concerns that the billionaire's erratic behavior could destabilize the social media company's business, and hurt it financially.