Chiefs quarterback Mahomes, 27, will face Philadelphia Eagles counterpart Jalen Hurts, 24, in Arizona on 12 February.
BBC reports Mahomes is a previous winner with the Chiefs having triumphed in 2020.
"To be on the world stage with two Black quarterbacks starting, I think it's special," said Mahomes.
Mahomes, who helped guide the Chiefs past the Cincinnati Bengals to reach the Super Bowl, paid tribute to former black quarterbacks including Doug Williams, who was the first to start in and win the NFL's showpiece event with the Washington franchise in 1988.
