Ziona Chana, the head of a religious sect that practiced polygamy, died on Sunday, leaving behind 38 wives, 89 children and 36 grandchildren.
The news was confirmed by Mizoram's chief minister, Zoramthanga, who offered his condolences on Twitter "with a heavy heart".
Chana reportedly suffered from diabetes and hypertension.
Doctors told PTI news agency that Chana's condition deteriorated at home in his village, Baktawng Tlangnuam. He was rushed to hospital on Sunday evening, where he was declared dead on arrival.