The 33-year-old Kepu, who last year became the first prop to play 100 Tests for Australia, announced on Monday his plans to step down from international rugby.
It brings to an end his ties to Australian rugby after quitting the NSW Waratahs to play with UK club London Irish after the global tournament in Japan, which starts later this month.
Kepu is set to farewell fans at the Wallabies' final World Cup warm-up game, against Samoa at Sydney's Bankwest Stadium on Saturday.