The five-figure penalties on the two flyers accused of violence are part of $US2 million ($NZ2.9m) in fines levied this year.
US airlines have seen record numbers of disruptive passengers since early 2021, with many incidents involving the refusal to wear an anti-viral facemask.
The fines were announced by transport secretary Pete Buttigieg on Friday.
"If you are on an airplane, don't be a jerk and don't endanger the flight crews and fellow passengers," he said in an appearance on ABC's The View. "If you do, you will be fined by the FAA."