Also known as the Golden Raspberry Awards, the ceremony celebrates the worst films of the year. Recent winners include Cats and The Emoji Movie.
Downey Jr is up for worst actor and "worst screen combo" for teaming up with his "unconvincing Welsh accent".
Dolittle was described as "shockingly poor" by BBC film critic Mark Kermode.
The Irish Times described it as "the low-point of every single career involved", while The Guardian said: "Every time Downey opens his mouth to say something unintelligible, the film dies a bit more."
