She had a high threshold for pain, which meant she didn't feel burns or notice broken bones. Five other family members are also affected by the condition which means they are insensitive to pain.
Letizia told the BBC: "From day to day we live a very normal life, perhaps better than the rest of the population, because we very rarely get unwell and we hardly feel any pain.
"However, in truth, we do feel pain, the perception of pain, but this only lasts for a few seconds."
Scientists believe the condition could be down to some nerves not reacting properly.