The 19-year-old Papali'i limped off early in last week's 20-8 win over Gold Coast and has since been ruled out for up to six weeks with a medial knee ligament sprain.
He'll be replaced in the second row by ex-Titan Pulu, who has twice started on the bench this season and will line up alongside Tohu Harris and lock Ligi Sao.
As a result, fellow Warriors recruit Agnatius Paasi comes onto the bench, where he'll join another new face in Jazz Tevaga, who replaces Sam Cook.
Coach Stephen Kearney talked up Pulu's NRL pedigree.