It leaves players including captain Owen Farrell, Maro Itoje and the Vunipola brothers without a game before England face Scotland on 6 February.
Saracens were relegated from the Premiership earlier this year after breaching salary cap rules.
English rugby's second tier has not had a game since March due to Covid-19.
To counter the lack of preparation, Saracens have confirmed they are negotiating with fellow clubs to establish a separate cup competition format as part of the pre-season build up, sanctioned by the Rugby Football Union.
